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Conditions

Off-Guard

Imposes a −2 circumstance penalty to AC while distracted or unable to defend effectively. Applied by Grabbed, Restrained, Paralyzed, Prone (melee only), Unconscious, Hidden, Undete...

You are distracted or otherwise unable to defend yourself effectively. You take a −2 circumstance penalty to AC.

Many conditions impose Off-Guard: Grabbed, Restrained, Paralyzed, Prone (against melee attackers only), Unconscious, and being Hidden or Undetected from a creature. Flanking also grants Off-Guard in many situations.